Na dihydrocoumarin e chefo

Dihydrocoumarin, monko o monate, e sebediswang dijong, e sebediswa hape e le sebaka sa coumarin, e sebediswa e le tatso ya setlolo; Kreime e kopantsweng, kokonate, tatso ya sinamone; E sebediswa hape e le tatso ya koae.

Na dihydrocoumarin e chefo

Dihydrocoumarin ha e na chefo. Dihydrocoumarin ke sehlahisoa sa tlhaho se fumanoang ka har'a rhinoceros e mosehla ea vanilla. E lokisoa ka hydrogenation ea coumarin ka har'a nickel catalyst ho 160-200 ℃ le tlas'a khatello. E ka boela ea sebelisoa e le thepa e tala, e hydrolyzed ka tharollo ea metsi a alkaline ho hlahisa o-hydroxyphenylpropionic acid, dehydration, closed-loop e fumanoeng.

Boemo ba polokelo

E koetsoe ebile e le lefifi, e bolokiloe sebakeng se pholileng le se omileng, sebaka se ka har'a moqomo se senyenyane kamoo ho ka khonehang tlas'a tumello ea polokeho, 'me se tletse tšireletso ea naetrojene. Boloka ntlong ea polokelo e pholileng, e nang le moea o kenang. Lula hole le mollo, metsi. E lokela ho bolokoa ka thoko ho oxidizer, u se ke ua kopanya polokelo. E hlomelitsoe ka mefuta e fapaneng le bongata bo loketseng ba lisebelisoa tsa mollo.

Thuto ea ka hare ho 'mele

Teko ea enzymatic ea in vitro, dihydrocoumarin e bakile thibelo e itšetlehileng ka mahloriso ea SIRT1 (IC50 ea 208μM). Phokotso ea ts'ebetso ea deacetylase ea SIRT1 e bonoe esita le ka tekanyo ea micromolar (ts'ebetso ea 85±5.8 le 73± 13.7% ho 1.6μM le 8μM, ka ho latellana). Microtubule SIRT2 deacetylase le eona e ile ea thibeloa ka mokhoa o ts'oanang o itšetlehileng ka tekanyo (IC50 ea 295μM).

Kamora lihora tse 24 tsa ho pepesehela, dihydrocoumarin (1-5mM) e ekelitse chefo ea cytotoxic meleng ea lisele tsa TK6 ka mokhoa o itšetlehileng ka tekanyo. Dihydrocoumarin (1-5mM) e ekelitse apoptosis meleng ea lisele tsa TK6 ka mokhoa o itšetlehileng ka tekanyo nakong ea lihora tse 6. Tekanyo ea 5mM ea dihydrocoumarin e ekelitse apoptosis nakong ea lihora tse 6 moleng oa sele ea TK6. Kamora nako ea ho pepesehela lihora tse 24, dihydrocoumarin (1-5mM) e ekelitse p53 lysine 373 le 382 acetylation ka mokhoa o itšetlehileng ka tekanyo moleng oa sele ea TK6.