Dihydrocoumarin e na le chefo

Dihydrocoumarin, monko o monate, o sebelisoang lijong, hape o sebelisoa e le sebaka sa coumarin, se sebelisoang e le tatso ea setlolo; Kopanya tranelate, kokonate, tatso ea sinamone; E boetse e sebelisoa e le tatso ea koae.

Dihydrocoumarin e na le chefo

Dihydrocoumarin ha e na chefo. Dihydrocoumarin ke sehlahisoa sa tlhaho se fumanehang ho tšukulu ea vanilla e mosehla. E lokiselitsoe ke hydrogenation ea coumarin ka boteng ba nickel catalyst ho 160-200 ℃ le tlas'a khatello. E ka boela ea sebelisoa e le thepa e tala, hydrolyzed ka alkaline aqueous tharollo ho hlahisa o-hydroxyphenylpropionic acid, dehydration, koaloa-loop fumanoa.

Boemo ba polokelo

E koetsoe ebile e lefifi, e bolokiloe sebakeng se pholileng le se omileng, sebaka se ka har'a barrel se senyenyane ka hohle kamoo ho ka khonehang tlas'a tumello ea tšireletso, 'me se tletse tšireletso ea naetrojene. Boloka sebakeng se pholileng, se nang le moea oa ho boloka moea. Lula hole le mollo, metsi. E lokela ho bolokoa ka thoko ho oxidizer, u se ke ua kopanya polokelo. E na le mefuta e fapaneng e lumellanang le bongata ba lisebelisoa tsa mollo.

Thuto ea in vitro

In vitro enzymatic assay, dihydrocoumarin e kentse inhibition e itšetlehileng ka mahloriso ea SIRT1 (IC50 ea 208μM). Phokotso ea ts'ebetso ea SIRT1 ea deacetylase e ile ea bonoa esita le ho litekanyetso tsa micromolar (85 ± 5.8 le 73 ± 13.7% ts'ebetso ho 1.6μM le 8μM, ka ho latellana). Microtubule SIRT2 deacetylase e ne e boetse e thibetsoe ka mokhoa o ts'oanang o itšetlehileng ka lethal dose (IC50 ea 295μM).

Ka mor'a lihora tse 24 tsa ho pepeseha, dihydrocoumarin (1-5mM) e ile ea eketsa cytotoxicity meleng ea lisele tsa TK6 ka mokhoa o itšetlehileng ka tekanyo. Dihydrocoumarin (1-5mM) e ekelitse apoptosis meleng ea lisele tsa TK6 ka mokhoa o itšetlehileng ka tekanyo ea nako ea lihora tse 6. Tekanyetso ea 5mM ea dihydrocoumarin e ekelitse apoptosis ka nako ea lihora tse 6 moleng oa lisele tsa TK6. Ka mor'a nako ea ho pepeseha ha lihora tse 24, dihydrocoumarin (1-5mM) e eketsehile p53 lysine 373 le 382 acetylation ka mokhoa o itšetlehileng ka tekanyo ea lisele tsa TK6.