Jwalo ka aliphatic dibasic aldehyde e tletseng ketane e otlolohileng, glutaraldehyde ke mokelikeli o bonaletsang o se nang mmala o nang le monko o halefisang le phello e ntle ya ho bolaya dibaktheria tsa ho ikatisa, divaerase, mycobacteria, hlobo ya pathogenic le baktheria ya baktheria, le bactericide e sa qhibilihiseng ya di-spectrum tse pharaletseng. Glutaraldehyde ke sebolaya dikokwana-hloko se sebetsang hantle haholo se bolayang mefuta e fapaneng ya dikokwana-hloko mme se kgothaletswa ke Mokgatlo wa Lefatshe wa Bophelo e le sebolaya dikokwana-hloko bakeng sa ditshila tsa kokoana-hloko ya hepatitis.
Glutaraldehyde 25%E na le litlamorao tse hlasimollang le tse folisang letlalong la motho le lera la mucous 'me e ka baka allergy, kahoo ha ea lokela ho sebelisoa bakeng sa ho bolaea likokoana-hloko tsa moea le lisebelisoa tsa lijo. Ho phaella moo, glutaraldehyde ha ea lokela ho sebelisoa bakeng sa ho bolaea likokoana-hloko le ho bolaea likokoana-hloko tsa lisebelisoa tsa bongaka tsa tubular, linalete tsa ente, li-suture tsa opereishene le likhoele tsa k'hothone.
Glutaraldehyde e atisa ho sebelisoa e le sebolaya-ditwatsi indastering ea bongaka 'me basebelisi ba ka ba le lipotso tse amanang le mathata a tekheniki, kahoo Springchem mona e fana ka lintlha tsa bohlokoa mabapi le glutaraldehyde bakeng sa litšupiso tsa hau.
Aho kenngoa ha glutaraldehyde
Glutaraldehyde e sebelisoa e le sebolaya-mafu se batang ho bolaea likokoana-hloko lisebelisoa tse utloang mocheso, tse kang li-endoscope le lisebelisoa tsa dialysis. E sebelisoa e le sebolaya-mafu sa boemo bo holimo bakeng sa lisebelisoa tseo tsa ho buoa tse ke keng tsa hloekisoa mochesong.
Glutaraldehyde e sebelisoa bakeng sa lits'ebetso tse 'maloa litsing tsa tlhokomelo ea bophelo:
● Moriana oa ho lokisa lisele tsa 'mele lilaboratoring tsa pathology
● Sebolaya-mafu le ho bolaea likokoana-hloko holim'a libaka le lisebelisoa
● Sehlahisoa se thatafatsang se sebelisetsoang ho etsa mahlaseli a X
● Bakeng sa ho lokisa li-graft
Nako ea ho felaletsatsi la glutaraldehyde le mokhoa oa ho fumana hore na e fela neng
Mochesong oa kamore le tlas'a boemo ba ho ba hole le polokelo e khanyang le e koetsoeng, letsatsi la ho fela ha glutaraldehyde ha ea lokela ho ba ka tlase ho lilemo tse 2, 'me karolo e sebetsang ea glutaraldehyde e lokela ho ba bonyane 2.0% ka har'a letsatsi la ho fela.
Mochesong oa kamore, kamora ho eketsa sesebelisoa sa ho thibela mafome le sesebelisoa sa ho lokisa pH, glutaraldehyde e sebelisoa bakeng sa ho bolaea likokoana-hloko kapa ho sterilization ea lisebelisoa tsa bongaka, 'me e ka sebelisoa matsatsi a 14 a latellanang. Sekhahla sa glutaraldehyde e lokela ho ba bonyane 1.8% nakong ea ts'ebeliso.
Ho qoelisoadtšoaetsomokhoae nang le glutaraldehyde
Inela disebediswa tse hlwekisitsweng ka tharollo ya 2.0% ~ 2.5% ya glutaraldehyde ho di qoelisa ka botlalo, ebe o kwahela setshelo sa dibolaya-ditwatsi mochesong wa kamore metsotso e 60, mme o di hlatswe ka metsi a hlwekileng pele o di sebedisa.
Lisebelisoa tsa tlhahlobo le kalafo tse hloekisitsoeng le tse omisitsoeng, lisebelisoa le lintho tse ling li kenngoa ka har'a tharollo ea 2% ea alkaline glutaraldehyde e qoelitsoeng ka botlalo, 'me lipululana tsa moea tse holim'a lisebelisoa li lokela ho tlosoa ka setshelo se koahetsoeng mochesong oa 20 ~ 25℃. Ho bolaea likokoana-hloko ho sebetsa ho fihlela nako e boletsoeng ea litaelo tsa sehlahisoa e fihla.
Litlhoko tsa ho bolaea likokoana-hloko tsa endoscope ka glutaraldehyde
1. Litekanyetso tsa boemo bo holimo tsa ho bolaea likokoana-hloko le ho bolaea likokoana-hloko
● Ho tsepamisa maikutlo: ≥2% (alkaline)
● Nako: bronchoscopy nako ea ho qoelisa ka ho bolaea likokoana-hloko ≥ metsotso e 20; endoscope tse ling ho qoelisa ka ho bolaea likokoana-hloko ≥ metsotso e 10; ho qoelisa ka ho ntša likokoana-hloko ka ho sebelisa endoscopic bakeng sa bakuli ba nang le lefuba la mycobacterium, libaktheria tse ling tsa mycobacteria le tšoaetso e 'ngoe e khethehileng ≥ metsotso e 45; ho sterilization ≥ lihora tse 10
2. Sebelisa mokhoa
● Mochini oa ho hloekisa le ho bolaea likokoana-hloko oa endoscope
● Ts'ebetso ea letsoho: sebolaya-mafu se lokela ho tlatsoa ka phaephe e 'ngoe le e 'ngoe 'me se kolobisoe ho sebolaya-mafu
3. Litlhokomelo
Glutaraldehyde 25%e baka alejiki mme e halefisa letlalo, mahlo le moya, mme e ka baka dermatitis, conjunctivitis, ho ruruha ha nko le asma ya mosebetsi, kahoo e lokela ho sebediswa mochining wa ho hlwekisa le ho bolaya dikokwana-hloko wa endoscope.
Litlhokomelo tse nang le glutaraldehyde
Glutaraldehyde e halefisa letlalo le lera la mucous mme e na le chefo ho batho, mme tharollo ya glutaraldehyde e ka baka tshenyo e kgolo mahlong. Ka hona, e lokela ho lokiswa le ho sebediswa sebakeng se nang le moya o kenang hantle, tshireletso ya motho ka mong e lokela ho lokiswa hantle, jwalo ka ho roala dimaseke tse sireletsang, diatlana tse sireletsang le digalase tse sireletsang. Haeba e ka kopana le yona ka phoso, e lokela ho hlatsuwa hanghang le ka ho tswela pele ka metsi, mme tlhokomelo ya bongaka e lokela ho batlwa pele haeba mahlo a lemetse.
E lokela ho sebelisoa sebakeng se nang le moea o kenang hantle, 'me haeba ho hlokahala, sebaka seo se lokela ho ba le lisebelisoa tsa ho ntša mosi. Haeba bongata ba glutaraldehyde moeeng sebakeng seo ho sebelisoang ho sona bo le holimo haholo, ho khothaletsoa hore e be le lisebelisoa tsa ho hema tse ikemetseng (mask e sireletsang khatello e ntle). Lijana tse sebelisetsoang ho inela li tlameha ho hloeka, ho koaheloa le ho hloekisoa ka likokoana-hloko pele li sebelisoa.
Ho beha leihlo maqhubu a glutaraldehyde
Khatello e sebetsang ea glutaraldehyde e ka hlahlojoa ka lik'hemik'hale tsa liteko.
Nakong ea tšebeliso e tsoelang pele, tlhokomelo ea letsatsi le letsatsi e lokela ho matlafatsoa ho utloisisa liphetoho tsa mahloriso a eona, 'me ha ea lokela ho sebelisoa hang ha mahloriso a eona a fumanoa a le ka tlase ho mahloriso a hlokahalang.
Ho lokela ho netefatsoa hore bongata ba glutaraldehyde bo sebelisoang bo fihlela litlhoko tsa bukana ea litaelo tsa sehlahisoa.
E lokela hoglutaraldehyde e lokela ho kenngwa tshebetsong pele e sebediswa?
Tharollo ea metsi ea glutaraldehyde e na le asiti 'me hangata e ke ke ea bolaea li-spores tse melang boemong ba asiti. Ke feela ha tharollo e "kenngoa tšebetsong" ke alkalinity ho ea ho boleng ba pH ba 7.5-8.5 moo e ka bolaeang li-spores. Hang ha li se li kentsoe tšebetsong, litharollo tsena li na le bophelo ba shelefo ba bonyane matsatsi a 14. Maemong a pH ea alkaline, limolek'hule tsa glutaraldehyde li atisa ho ba polymerize. Polymerization ea glutaraldehyde e fella ka ho koaloa ha sehlopha se sebetsang sa aldehyde sa molek'hule ea eona ea glutaraldehyde se ikarabellang bakeng sa ho bolaea li-spores tse melang, kahoo phello ea baktheria ea fokotseha.
Mabaka a amang ho bola ha glutaraldehyde
1. Ho tsepamisa maikutlo le nako ea ketso
Tšusumetso ea ho bolaea libaktheria e tla ntlafala ka keketseho ea mahloriso le katoloso ea nako ea ketso. Leha ho le joalo, tharollo ea glutaraldehyde e nang le karolo e boima ea ka tlase ho 2% e ke ke ea finyella phello e tšepahalang ea ho bolaea libaktheria holim'a li-spores tsa baktheria, ho sa tsotelehe hore na e ka eketsa nako ea ho bolaea libaktheria joang. Ka hona, ho hlokahala ho sebelisa tharollo ea glutaraldehyde e nang le karolo e boima e fetang 2% ho bolaea li-spores tsa baktheria.
2. Tharollo ea asiti le alkalinity
Tšusumetso ea ho bolaea libaktheria ea acid glutaraldehyde e tlase haholo ho feta ea alkaline glutaraldehyde, empa phapang e tla fokotseha butle-butle ha mocheso o ntse o eketseha. Maemong a pH 4.0-9.0, phello ea ho bolaea libaktheria e eketseha ha pH e ntse e eketseha; phello e matla ka ho fetisisa ea ho bolaea libaktheria e bonoa ho pH 7.5-8.5; ha pH e feta 9, glutaraldehyde e fetoha polymer ka potlako 'me phello ea ho bolaea libaktheria e lahleha kapele.
3. Mocheso
E boetse e na le phello ea ho bolaea libaktheria mochesong o tlase. Tšusumetso ea ho bolaea libaktheria ea glutaraldehyde e eketseha ha mocheso o ntse o phahama, 'me coefficient ea eona ea mocheso (Q10) ke 1.5 ho isa ho 4.0 ho 20-60℃.
4. Lintho tse phelang
Lintho tse phelang li etsa hore phello ea ho bolaea libaktheria e fokole, empa phello ea lintho tse phelang phellong ea ho bolaea libaktheria ea glutaraldehyde e nyane ho feta ea li-disinfectants tse ling. 20% ea serum ea namane le 1% ea mali a felletseng ha li na phello phellong ea ho bolaea libaktheria ea 2% ea glutaraldehyde.
5. Phello e kopanetsoeng ea li-surfactants tse seng tsa ionic le lintlha tse ling tsa fisik'hemik'hale
Polyoxyethylene fatty alcohol ether ke surfactant e seng ea ionic, 'me botsitso le phello ea baktheria li ntlafala haholo ka ho eketsa 0.25% polyoxyethylene fatty alcohol ether ho tharollo ea glutaraldehyde e entsoeng ka glutaraldehyde e ntlafalitsoeng ea acid-base. Ultrasound, mahlaseli a far infrared le glutaraldehyde li na le phello ea synergistic sterilization.
Springchem, moetsi oa glutaraldehyde ea 10 ea holimo Chaena, e fana ka glutaraldehyde 25% le 50% bakeng sa merero ea indasteri, laboratori, temo, bongaka le merero e meng ea malapa, haholo-holo bakeng sa ho bolaea likokoana-hloko le ho bolaea likokoana-hloko holim'a libaka le lisebelisoa. Bakeng sa tlhaiso-leseling e batsi, ikopanye le rona feela.
Nako ea poso: Phato-16-2022